Renin and cardiovascular disease: Worn-out path, or new direction

The renin angiotensin system and cardiovascular disease: hope or hype?

Introduction Inhibition of the renin-angiotensin-aldosterone system (RAAS) either via ACE-inhibition, or more recently via the use of angiotensin II receptor antagonists (AIIAs), has become an important therapeutic tool for the treatment of hypertension and its cardiovascular sequelae. Basic scientific investigation of the pathophysiology of cardiovascular disease has revealed many compelling r...

A Worn-Out Welcome

A 298 W hen Iceland became the first country to ban most forms of asbestos in 1983, 1 global use hovered around 4.3–4.7 million metric tons per year. 2 Twenty-five years later, with several dozen countries now implementing some form of ban, 1 that number had dropped to 2.1 million metric tons. 3 Today, while demand has plummeted in most developed countries, it continues to rise in those countri...

Cardiovascular disease and genetics of the renin-angiotensin system.

Behcet's Disease: New Concepts in Cardiovascular Involvements and Future Direction for Treatment

Behcet's disease (BD) is the only systemic vasculitis involving both arteries and vein in any sizes. It frequently encounters in rheumatology clinics. It has some major morbidities and even fatal outcomes in some cases. The aim of this paper is to analyze the main concepts on pathophysiology and treatment options in BD, focusing on cardiovascular aspects, thrombosis, and potential future treatm...

Ambulatory paediatrics: stepping out in a new direction?

Background In 1976 the Court report recommended the rationalisation of child health services in England and Wales,' and although it has taken longer than hoped and the terminology has changed along the way,2 there has been real progress towards the achievement of 'combined' and 'integrated' children's services, with 'seamless' care at the point of delivery of care. Recently, the Audit Commissio...